Biokinetics and dosimetry of 111In-DOTA-NOC-ATE compared with 111In-DTPA-octreotide
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چکیده
منابع مشابه
Ectopic Cushing's syndrome and pulmonary carcinoid tumour identified by [111In-DTPA-D-Phe1]octreotide.
The differential diagnosis and management of Cushing's syndrome remain difficult, particularly for ectopic adrenocorticotropin (ACTH) syndromes resulting from small bronchial carcinoids. We report the case of a 41-year-old man with ectopic ACTH-dependent Cushing's syndrome. Two computed tomography scans of the thorax were normal and magnetic resonance imaging of the chest showed a 6-mm hyperint...
متن کاملImproved labelling of DTPA- and DOTA-conjugated peptides and antibodies with 111In in HEPES and MES buffer
BACKGROUND In single photon emission computed tomography [SPECT], high specific activity of 111In-labelled tracers will allow administration of low amounts of tracer to prevent receptor saturation and/or side effects. To increase the specific activity, we studied the effect of the buffer used during the labelling procedure: NaAc, NH4Ac, HEPES and MES buffer. The effect of the ageing of the 111I...
متن کاملDiffuse lung uptake of 111In octreotide from chronic emphysema.
A 62-y-old woman was found to have a lung mass and a brain mass. The brain mass was resected, and the histopathologic findings were suggestive of a gastrointestinal primary tumor with neuroendocrine features. She was referred for an 111In-octreotide SPECT/CT scan to evaluate for somatostatin-avid disease. After injection of 222 MBq (6 mCi) of 111In-octreotide, planar SPECT images (Fig. 1A) and ...
متن کاملIncreased uptake of 111In-octreotide in idiopathic pulmonary fibrosis.
UNLABELLED Idiopathic pulmonary fibrosis (IPF) is characterized by an uncontrolled accumulation and activation of lung fibroblasts. A modulation of fibroblast activation has been observed in various systems with octreotide, a synthetic somatostatin analog with strong affinity for the somatostatin receptor subtype 2 (sst2). One aim of our study was to evaluate the expression of somatostatin rece...
متن کاملAn intrapatient comparison of 99mTc-EDDA/HYNIC-TOC with 111In-DTPA-octreotide for diagnosis of somatostatin receptor-expressing tumors.
UNLABELLED The aim of this study was to compare the imaging abilities of the recently developed somatostatin analog, (99m)Tc-hydrazinonicotinyl-Tyr(3)-octreotide ((99m)Tc-HYNIC-TOC [(99m)Tc-TOC]), with (111)In-diethylenediaminepentaacetic acid-D-Phe(1)-octreotide ((111)In-OCT [Octreoscan]) in patients undergoing routine somatostatin receptor (SSTR) scintigraphy. METHODS Forty-one patients (20...
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ژورنال
عنوان ژورنال: European Journal of Nuclear Medicine and Molecular Imaging
سال: 2012
ISSN: 1619-7070,1619-7089
DOI: 10.1007/s00259-012-2210-0